|
Hypertensive disease
|
0.370 |
AlteredExpression
|
group |
BEFREE |
CR in ischemic stroke patients is associated with several independent predictors, including increased platelet activation marker CD62p, decreased vitamin D level, and hypertension.
|
30795966 |
2019 |
|
Myocardial Ischemia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We present evidence that genetic disruption of PARS provides protection against myocardial ischemia and reperfusion injury by inhibiting the expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) and, consequently, by inhibiting the recruitment of neutrophils into the jeopardized tissue.
|
9670921 |
1998 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compound 6b also inhibited platelet P-selectin expression and thus may diminish atherosclerosis.
|
27996269 |
2017 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis.
|
21763287 |
2011 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We have investigated whether gallic acid (GA), an abundant red wine polyphenol, modulates the activity of P-selectin, an adhesion molecule that is critically involved in the recruitment of inflammatory cells to the vessel wall and thus in atherosclerosis.
|
15630039 |
2005 |
|
Myocardial Infarction
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Acute myocardial infarction and ischemic stroke are associated with high platelet reactivity on clopidogrel in 6-58% of patients when assessed with P-selectin expression, and high reactivity was associated with an increased risk of recurrence after myocardial infarction.
|
29667460 |
2018 |
|
Colitis
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, apoA-IV dramatically reduced the upregulation of P-selectin on colonic endothelium during DSS-colitis. apoA-IV knockout mice exhibited a significantly greater inflammatory response to DSS than did their WT littermates; this greater susceptibility to DSS-induced inflammation was reversed upon exogenous administration of apoA-IV to knockout mice.
|
15254593 |
2004 |
|
Congestive heart failure
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Fractalkine significantly aggravated endothelial dysfunction and augmented P-selectin expression on platelets from CHF rats.
|
24336891 |
2014 |
|
Anemia, Sickle Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sickle cell disease promotes an increased P-selectin expression in several vascular beds.
|
15280076 |
2004 |
|
Anemia, Sickle Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined the mechanism of mast cell-induced endothelial activation <i>via</i> endoplasmic reticulum (ER) stress mediated P-selectin expression in a transgenic mouse model of sickle cell disease (SCD), which shows BBB dysfunction.
|
30837844 |
2019 |
|
Anemia, Sickle Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vascular function in SCD::Keap1F/F::Tie1-Cre mice was significantly improved, with a 50% decrease in vascular leakage and low expression of the adhesion molecules Vcam1 and P-selectin.
|
31015205 |
2019 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis.
|
21763287 |
2011 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have investigated whether gallic acid (GA), an abundant red wine polyphenol, modulates the activity of P-selectin, an adhesion molecule that is critically involved in the recruitment of inflammatory cells to the vessel wall and thus in atherosclerosis.
|
15630039 |
2005 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compound 6b also inhibited platelet P-selectin expression and thus may diminish atherosclerosis.
|
27996269 |
2017 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The more pronounced correlation for the expression of CD54 and CD62 L in cancer suggests that monocytes uptake from the bloodstream and their local adhesion increase the pool of tumor-associated macrophages.
|
25880896 |
2015 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Laser scanning confocal microscopy was employed to assay the expression of P-selectin in lung cancer tissue, paracancerous tissue and distant tissue, respectively.
|
22266541 |
2012 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased levels of soluble P-selectin have been reported in various cardiovascular disorders.
|
11597943 |
2001 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Soluble P-selectin level correlates with acetylsalicylic acid but not with clopidogrel response in patients with stable coronary artery disease after a percutaneous coronary intervention.
|
23549485 |
2013 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, this study revealed a strong association between P-selectin gene polymorphisms and serum P-selectin levels and a complex age-dependent relation between soluble P-selectin levels and coronary artery disease, which suggests that this molecule might have different roles in the atherothrombotic process.
|
11597943 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus.
|
27975100 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pre-administration with SA increased both platelet CD62P expression and TXB<sub>2</sub>/6-keto-PGF<sub>1α</sub> ratio in female T2DM mice, while pretreatment with NaHCO<sub>3</sub> caused the opposite effect.
|
27894813 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy.
|
19228864 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The platelets from patients with T2DM had higher levels of CD62P expression before any stimulation (P = 0.003) than control samples.
|
31200678 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among those with type 2 diabetes, in multivariate models adjusted for age, sex, and other traditional risk factors, higher P-selectin levels were associated with any DR (odds ratio = 1.11, 95% confidence interval = 1.02-1.21, P = .02) and proliferative DR (odds ratio = 1.23, 95% confidence interval = 1.03-1.46, P = .02).
|
25794792 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with T2DM had higher levels of fibrin (P=0.03), P-selectin (P=0.0001), PAI-1 (P=0.03) and vWF (P=0.006) in the thrombus and higher plasma TF activity (P=0.01) compared to non-diabetics.
|
28747040 |
2017 |